kidney releases a non-polymerizing form of Uromodulin in the urine and circulation that retains the external hydrophobic patch

Processing of mature urinary THP, which polymerizes into supra-molecular filaments, requires cleavage of an external hydrophobic patch (EHP) at the C-terminus. However, THP in the circulation is not polymerized, and it remains unclear if non-aggregated forms of THP exist natively in the urine. We propose that an alternative processing path, which retains the EHP domain, can lead…

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Lipid Peroxidation

Lipid Peroxidation (MDA) Assay Bundle (Colorimetric/Fluorometric) 

Related merchandise Evaluation the oxidative stress marker and assay info, or the whole metabolism assay info to check additional assays for metabolites, metabolic enzymes, mitochondrial function, and oxidative stress, and as well as how one can assay metabolic function in dwell cells using your plate reader. Moreover see the favored 4-HNE Assay Bundle ab238538 instead marker of lipid peroxidation and…

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Epigentek

Chromatin immunoprecipitation (ChIP)

Background Knowledge Chromatin immunoprecipitation (ChIP) offers an advantageous system for locating out protein-DNA interaction. With ChIP, the experimenter can determine if a specific protein binds to the exact sequences of a gene in residing cells by combining it with PCR (ChIP-PCR), microarray (ChIP-chip), or sequencing (ChIP-Seq) strategies. As an illustration, the measurement of the amount…

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innovexbio background buster

Background staining or non-specific staining buster peptide blocker

INTRODUCTION Background staining or non-specific staining is an often-encountered disadvantage in immunohistochemistry (IHC), in immunofluorescence labeling (IF) and in situ stains. Background staining is attributable to varied parts equivalent to cross reactivity of antibodies with the shared epitopes throughout the tissue, by the presence of pure and/or contaminating antibodies present throughout the main antibody and/or…

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