kidney releases a non-polymerizing form of Uromodulin in the urine and circulation that retains the external hydrophobic patch

• Bailey
• February 3, 2022November 5, 2022
• 0

Processing of mature urinary THP, which polymerizes into supra-molecular filaments, requires cleavage of an external hydrophobic patch (EHP) at the C-terminus. However, THP in the circulation is not polymerized, and it remains unclear if non-aggregated forms of THP exist natively in the urine. We propose that an alternative processing path, which retains the EHP domain, can lead…