kidney releases a non-polymerizing form of Uromodulin in the urine and circulation that retains the external hydrophobic patch

Processing of mature urinary THP, which polymerizes into supra-molecular filaments, requires cleavage of an external hydrophobic patch (EHP) at the C-terminus. However, THP in the circulation is not polymerized, and it remains unclear if non-aggregated forms of THP exist¬†natively in the urine. We propose that an alternative¬†processing path, which retains the EHP domain, can lead…

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