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Regulatory forum opinion essay: The role of the toxicological pathologist in the post-genomic era: challenges and opportunities.

The revolutions of ‘Omics’, high-throughput screening, computer modeling, and database mining have come with exhilarating predictions and concrete hand cues, guarantees to prioritize toxicity testing and reduce reliance on standard tests. Referring to previous experience with various predictive methods and options, what follows frenzy to support promising new knowledge or an entirely different method of testing for toxicity/carcinogenicity is years of knowledge refinement for verification and improvement. Much enthusiasm for each new method and emerging technology is the costly, time-consuming, and often irrelevant and ineffective rodent biological testing paradigm.

However, one should not expect to abandon all animal testing for the foreseeable future, particularly for exposure to agrochemicals and environmental bio-exotics. It is cheap to expect that the long term will nonetheless provide new approaches to security testing and human threat assessment. In the past, each new method fell short of inflated expectations for security testing and human threat assessment, but it has often become a useful analytical tool with tangible contributions to elementary biology and scientific medicine.

The toxicologist has been integrated into a specialized mixed environmental matrix and faces some important challenges and fundamental post-genomic alternatives many years down the road. So what advice can we give an official toxicologist that we hope will work successfully within many years of genomics? And what additional advice can we give an experienced bench pathologist facing a burgeoning applied science, accompanied by a bewildering variety of technical jargon, so that he can maintain his competence as a toxicologist?

Post-genomic approaches to the use of Corynebacteria as biostimulators.

Corynebacterium glutamate reveals quite a few excellent intrinsic traits as a major and minor production unit of metabolism. The diversity of this organism has always been carried out on an industrial scale to provide a variety of amino acids with high yields and conversion rates, allowing the development of an entire industry. The post-genomic period provides a new technological platform not only to further improve the intrinsic properties of whole C. glutamicum cells as biostimulants, but also to develop the range of products that this organism can substantially synthesize, from amino acids to essential chemical compounds.

This overview addresses stress improvement strategies and methods that have been enabled by genomic information and related methods. Its implementation has enabled additional improvements necessary to the economics of industrial-scale manufacturing as C. glutamicum and its offshoots are used as an efficient host vector system. Regardless of the rapid development of post-genomic knowledge and the rapid development of technical knowledge, drug discovery remains a long and troublesome process. Simpler drug design requires a better understanding of the interaction between candidate drugs and targets/non-targets under many conditions.

The flexibility of proteomics to combine many disciplines allows direct assessment of protein actions on a broad range of proteins, which has tremendous potential to facilitate drug target elucidation and lead pharmacological investigation. In recent years, chemical proteomics have undergone rapid development and provided a useful technique for drug identification and inhibitor discovery. This overview provides the basic ideas and applied science for many standard chemical proteomics approaches. It also covers important options and recent advances in each method while highlighting their potential for drug discovery and improvement.

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Protein region prediction with selection and evaluation of mRMR features.

Domains are the structural and functional elements of proteins. With the torrent of protein sequences generated in the post-genomic era, there is a great need to develop effective strategies for predicting protein domains based on sequence information alone, in order to facilitate protein construct prediction and speed up protein annotation. However, despite numerous efforts in this regard, prediction of protein domains from sequencing data remains a complex and elusive problem. Here, a new technique has been developed that combines RF (random forest), mRMR (most relevant minimum frequency) and IFS (incremental feature selection) methods.

In addition to incorporating options for physical and biochemical properties, sequence conservation, residual dysfunction, secondary construction, and solvent accessibility. The overall success rate of the new method on an independent data set was about 73%, which is approximately 28-40% higher than the prevailing method on the same reference data set. Moreover, it was revealed by in-depth evaluation that evolutionary choices, codon range, electrostatic cost, and dysfunction played more important roles than others in the prediction of protein domains, based on experimental observations.

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