Proteomics Databasing with the CrystalLIMS™
The ultimate goal for the proteomics researcher is to solve the atomic structure of their protein. This is a long and difficult process. The first step is to get the protein to crystallize in a solution so that gamma rays can be used to map the structure. Complex recipes with multiple chemical reagents are explored to find the perfect combination to produce a suitable crystal for x-ray diffraction. Injection-molded plastic trays with 24 to 1536 independent wells are used to define and refine these recipes. Each well is an isolated atmosphere which allows the vapor diffusion process to occur independent of all other wells. A database application is used to track these 24 to 1536 unique recipes in each plate as well as the potentially hundreds of plates used to solve a single protein structure. CrystalLIMS™ is such a database, allowing researchers to track ingredients, score crystals, and optimize recipes to produce the finest quality crystal for their trip to the synchrotron.

For more information, please visit http://proteincrystalimaging.com